Publications

  • Multiparametric domain insertional profiling of adeno-associated virus VP1. (2023) Hoffmann M.D., Zdechlik A.C., He Y., Nedrud D., Aslanidi G., Gordon W., Schmidt D., Mol Ther Methods Clin Dev. 2023 Dec 14;31:101143. doi: 10.1016/j.omtm.2023.101143. eCollection 2023 Dec 14. PubMed PMID: 38027057; PubMed Central PMCID: PMC10661864. https://www.sciencedirect.com/science/article/pii/S2329050123001821

  • Development of an Inducible, Replication-Competent Assay Cell Line for Titration of Infectious Recombinant Adeno-Associated Virus Vectors. (2023) Lee Z., Lu M., Irfanullah E., Soukup M., Schmidt D., Hu W.S., Hum Gene Ther. 2023 Feb;34(3-4):162-170. doi: 10.1089/hum.2022.001. PubMed PMID: 36565023; PubMed Central PMCID: PMC10081724. https://www.liebertpub.com/doi/10.1089/hum.2022.001

  • Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning. (2022) Coyote-Maestas W., Nedrud D., He Y., Schmidt, D., Elife. 2022 May 31;11. doi: 10.7554/eLife.76903. PubMed PMID: 35639599; PubMed Central PMCID: PMC9273215. https://elifesciences.org/articles/76903

  • Probing Ion Channel Functional Architecture and Domain Recombination Compatibility by Massively Parallel Domain Insertion Profiling. Coyote-Maestas W., Nedrud D., Suma A., He Y., Matreyek K.A., Fowler D.M., Carnevale V., Myers C.L., Schmidt D. Nature Communications (2021) 2021 Dec 8;12(1):7114. doi: 10.1038/s41467-021-27342-0. https://www.nature.com/articles/s41467-021-27342-0

  • A large-scale survey of pairwise epistasis reveals a mechanism for evolutionary expansion and specialization of PDZ domains. Nedrud, D., Coyote-Maestas W., Schmidt D. Proteins (2021) Feb 23. doi: 10.1002/prot.26067, https://onlinelibrary.wiley.com/doi/10.1002/prot.26067

  • Programmable assembly of AAV-antibody composites for receptor-mediated gene delivery. Zdechlik A.C., He Y., Aird E., Gordon WR, Schmidt D. ACS Bioconjugate Chemistry (2019), https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00790

  • Targeted insertional mutagenesis libraries for deep domain insertion profiling. Coyote-Maestas W.†, Nedrud D.†, Okorafor S., He Y., Schmidt D. Nucleic Acid Research (2019) gkz1110, https://doi.org/10.1093/nar/gkz1110 †denotes equal contribution

  • Domain insertion permissibility-guided engineering of allostery in ion channels. Coyote-Maestas W., He Y., Myers C.L., Schmidt D. Nature Communications (2019) 10:290, https://doi.org/10.1038/s41467-018-08171-0

  • Combinatorial Assembly of Lumitoxins. Nedrud D., Schmidt D. Methods in Molecular Biology (2018) 1684:193-209, https://doi.org/10.1007/978-1-4939-7362-0_15

  • A fully genetically encoded protein architecture for optical control of peptide ligand concentration. Schmidt D., Tillberg P.W., Chen F., Boyden E.S. Nature Communications (2014) 4:3019, https://doi.org/10.1038/ncomms4019

  • Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels. Schmidt D., del Mármol J., MacKinnon R. Proc Natl Acad Sci U S A (2012) 109(26):10352-7. https://doi.org/10.1073/pnas.1204700109

  • Measuring cation dependent DNA polymerase fidelity landscapes by deep sequencing. Zamft B.M., Marblestone A.H., Kording K., Schmidt D., Martin-Alarcon D., Tyo K., Boyden E.S., and Church G. PLoS ONE (2012) 7, e43876.

  • Functional Reconstitution of a Voltage-Gated Potassium Channel in Giant Uni- lamellar Vesicles. Aimon S., Manzi J., Schmidt D., Poveda Larrosa J.A., Bassereau P., Tombes G.E.S. PLoS ONE (2011) 6(10): e25529 https://doi.org/10.1371/journal.pone.0043876

  • Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Schmidt D., MacKinnon R. Proc Natl Acad Sci U S A (2008) 105(49):19276-81. https://doi.org/10.1073/pnas.0810187105.

  • A gating model for the archeal voltage-dependent K(+) channel KvAP in DPhPC and POPE:POPG decane lipid bilayers. Schmidt D., Cross SR, MacKinnon R. J Mol Biol (2009) 390(5):902-12. https://doi.org/10.1016/j.jmb.2009.05.062.

  • Phospholipids and the origin of cationic gating charges in voltage sensors. Schmidt D., Jiang QX, MacKinnon R. Nature (2006) Dec 7;444(7120):775-9 https://doi.org/10.1038/nature05416

  • Homodimerization of the G protein SR-beta in the nucleotide-free state controlled by proline cis/trans isomerization in the switch II region. Schwartz T.U., Schmidt D., Brohawn S.G., Blobel G. (2006). Proc Natl Acad Sci U S A 103(18):6823-8 https://doi.org/10.1073/pnas.0602083103

  • The beta-subunit of the protein-conducting channel of the endoplasmic reticulum functions as the guanine nucleotide exchange factor for the beta-subunit of the signal recognition particle receptor. Helmers J., Schmidt D., Glavy J.S., Blobel G., Schwartz T.U. J Biol Chem (2003) 278(26): 23686-90 https://doi.org/10.1074/jbc.C300180200

Reviews

  • Natural photoreceptors and their application to synthetic biology Schmidt, D. & Cho, Y.K. Trends Biotechnol (2014)